In the News
Brian DeVree Receives a ProQuest Distinguished Dissertation Award for 2013
Chemical Biology alumnus Brian DeVree received a Proquest Distinguished Dissertation Award, which is given in recognition of the most exceptional scholarly work produced by doctoral students at the University of Michigan who completed their dissertations in 2013. Congratulations Brian!
Alisa Glukhova Awarded American Heart Association (AHA) Predoctoral Fellowship
Alisa Glukhova, a fourth year Chemical Biology student in Professor John Tesmer's laboratory, has been awarded an American Heart Association (AHA) Predoctoral Fellowship. Congratulations Alisa!
Matthew DeMars Awarded 2013 Cellular Biotechnology Training Program Fellowship
Matthew DeMars, first year Chemical Biology student in Professor David Sherman's laboratory has been selected to receive a fellowship by the Cellular Biotechnology Training Program. Congratulations!
New Students for Fall 2013
The Program in Chemical Biology is pleased to announce our new cohort for Fall 2013. There are 10 new students joining us at the University of Michigan this year! Welcome, Class of 2018!
Alison Tebo Awarded Chateaubriand Fellowship in Science, Technology, Engineering, and Mathematics (STEM)
Alison Tebo, a third year Chemical Biology student in Professor Vincent Pecoraro's laboratory, has been awarded a Chateaubriand Fellowship in Science, Technology, Engineering, and Mathematics (STEM). Congratulations Alison!
Two New Faculty Members Join the Program in Chemical Biology
We are pleased to welcome our newest faculty members to the Program in Chemical Biology starting this spring: Dr. Uhn-Soo Cho and Dr. Corinna Schindler.
GAANN Fellowship Awards for 2013
Chemical Biology first year students Matthew Beyersdorf, Osvaldo Cruz, Andrew Henderson, and Carrie Johnson have been chosen to receive GAANN Fellowships this year. Additionally, Victoria Assimon, JP Carolan, Laura Cesa, Corey Custer, Amanda Dugan, Felicia Gray, and Chris Tom have all been awarded senior GAANN fellowships. Congratulations to our students who have been selected!
Training Program Awards for 2012-2013
Rachel Pricer has been selected for fellowships in the Chemistry Biology Interface Training Program. She joins Alison Tebo, Carol Ann Pitcairn, and Conor Doss who were also awarded CBI training grant fellowships this year. Anne Gillies has also been selected to receive a fellowship by the Cellular Biotechnology Training Program. Congratulations to our students who have been selected!
Three New Faculty Members Join the Program in Chemical Biology
We are pleased to welcome three new faculty members to the Program in Chemical Biology starting this Fall: Dr. Sivaraj Sivaramakrishnan, Dr. Jorge Iniguez-Lluhi, and Dr. Gabrielle Rudenko.
Wendy Tay Awarded Alexander Graham Bell Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Scholarship
Wendy Tay, a fourth year Chemical Biology student in Professor Nils Walter's laboratory, has been awarded an Alexander Graham Bell Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Scholarship. Congratulations Wendy!
New Students for Fall 2012
The Program in Chemical Biology is pleased to announce our new cohort for Fall 2012. There are 11 new students joining us at the University of Michigan this year! Welcome, Class of 2017!
Leshern Karamchand Awarded NRF Free-standing Doctoral Scholarship for 2012
a third year Chemical Biology student in Professor Raoul Kopelman's laboratory, has been awarded a National Research Foundation Free-standing Doctoral Scholarship for 2012. These scholarship are awarded to top achievers in their research fields, for academic performance as well as their research potential. Congratulations Leshern!
Amanda Dugan Awarded Susan Lipschutz Award
a fourth year Chemical Biology student in Professor Anna Mapp's laboratory, has received the Susan Lipschutz Award. The Susan Lipschutz Award recognizes Rackham students who have demonstrated exceptional scholarly achievement, a sense of social responsibility and service, and a lively interest in promoting the success of women in the academic community.Congratulations Amanda!
Brian DeVree Awarded Rackham Predoctoral Fellowship
who is in his fourth year in Professor Roger Sunahara's laboratory, has received the Rackham Predoctoral Fellowship for the 2012-2013 year. Congratulations Brian!
Student Paper in Nature
Fourth year Chemical Biology student Brian DeVree and his advisor, Dr. Roger Sunahara, are authors on a trio of recent papers detailing structural studies of the β2 adrenergic receptor-Gs protein (β2AR-Gs) complex. The flagship article, on which DeVree is co-first author, reports for the first time an X-ray crystal structure of a G-protein coupled receptor in complex with its G protein (Rasmussen and DeVreeet al., Nature 477,549–555). The second paper reports the use of deuterium-hydrogen exchange mass spectrometry (DXMS) to study the dynamics of the β2AR-Gs interaction and thus complements the X-ray crystal structure (Chung et al., Nature 477,611–615). A third study, led by UM Chemical Biology professor Dr. Georgios Skiniotis, employs single particle electron microscopy to investigate the striking flexibility observed in a domain of the Gs protein (Westfield et al., PNAS 108(38) 16086-16091).
This seminal accomplishment is the culmination of several years of collaborative work between labs at several universities: Dr. Sunahara and Dr. Skiniotis here at UM, Dr. Brian Kobilka at Stanford University, and Dr. Virgil L. Woods, Jr. at the University of California-San Diego, along with considerable contributions from several other domestic and international labs. DeVree first got involved in the project when he came to UM as a lab technician working for Dr. Sunahara. He ultimately applied to and chose to enter the Program in Chemical Biology in 2008. Though he engaged in a productive rotation with Dr. Jason Gestwicki, he chose to take on the project he had started under Dr. Sunahara as his thesis research. DeVree spent a great deal of his time on protein purification and developing methods by which to achieve β2AR-Gs complex crystallization. Another Chemical Biology professor at UM, Dr. Janet Smith, contributed an important piece of the puzzle through the development of a specialized microfocus X-ray beamline at the Advanced Photon Source in Chicago. Without this beamline and its updated technology, the team would have had to travel to France to collect their data. DeVree and coworkers were finally able to obtain crystals that diffracted to sufficient resolution by using a combination of cutting edge crystallization techniques and solved the all-important structure earlier this year. DeVree has now co-authored seven papers with the Sunahara lab and hopes to continue carrying out groundbreaking research on the β2AR-Gs complexase.
New Students for Fall 2011
The Chemical Biology PhD Program is delighted to announce our incoming class for Fall 2011. We have 7 new students joining us. We are very pleased that they have decided to join us here at the University of Michigan.Welcome, class of 2016!
Training Program Awards for 2011-2012
Carol Ann Pitcairn and Conor Doss have bothe been selected for the Chemistry Biology Interface Training Program. Congratulations to our students who have been selected!
Yaru Zhang receives Barbour Scholarship
Yaru Zhang who is in her second year in the laboratory of Professor Pat O'Brien, is a recipient of the prestigous Rackham Barbour Scholarship for the 2011-2012 academic year. Congratulations Yaru!
Student Paper in MedChemComm
Chris Jones, who will be starting his second year with Professor Sylvie Garneau-Tsodikova, co-authored a paper that was featured on the cover of the journal MedChemComm. His work on novel bifunctional compounds to target Alzheimer's disease. See Bornstein, J.J., Eckroat, T.J., Houghton, J.L., Jones, C.K., Green, K.D., & Garneau-Tsodikova, S. (2011). Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase, MedChemComm, 2, 406-412
Student Paper in Nature.com
Fifth year Chemical Biology student Evgenia Nikolova has paper published on Nature.com
Professor Anna Mapp is quoted in an article on Chemical Biology and Medicinal Chemistry programs in Chemical & Engineering News. Read the article here.
Yaru Zhang awarded Rackham International Student Fellowship
Yaru Zhang who is in her second year in the laboratory of Professor Pat O'Brien, has received the Rackham International Student Fellowship for the winter 2011 term.
Student Receives ACS Medicinal Chemistry Fellowship
Jonas Westergaard Hojfeldt, who will be starting his fifth year in the laboratory of Professor Anna Mapp, has received the prestigious American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship for 2010-2011.
Professor Anna Mapp Announced as New Director for Chemical Biology Program
After 7 years of guidance and support from Professor Gary Glick the Chemical Biology Program is delighted to announce our new Director, Professor Anna Mapp. Anna is pleased to be leading the program and is excited about maintaining its growth and excellence.
Prestigious Rackham Predoctoral Fellowship Awarded
Evgenia Nikolova, a fourth year student in the Al-Hashimi Group, is a recipient of the prestigious Rackham Predoctoral Fellowship for 2010-2011. This fellowship provides a year of support to exceptional doctoral students who are in their final year of study.
Cover of January Issue of ChemBioChem
Wenjing Chen, a 3rd year student with Professor Sylvie Garneau-Tsodikova, co-authored a paper that was featured on the cover of the first 2010 issue of ChemBioChem. The cover picture shows the concept of utilizing enzymes that evolved in bacteria to confer resistance to antibiotics as a chemical tool to generate novel antibacterials with broad-spectrum activity. The article is titled "Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides". Click here to view the article.
Program Graduates first round of students
Tonia Buchholz from the Sherman lab successfully defended her thesis “Protein-Protein Interactions During Acyl Transfer In Polyketide Biosynthesis” making her the first graduate of the Chemical Biology Ph.D. Program
Andrew Stelzer from the Al-Hashimi lab defended his thesis “Characterizing HIV-1 Transactivation Response Element Dynamics that Govern Ligand Recognition: Direct Applications to Drug Discovery”.
Tasha Francis from the Glick lab defended her thesis “Target Identification and Validation of a Novel Family of Anti-Inflamatory 1,4-Benzodiazepine-2,5-Diones ”
Daniel Wahl also from the Glick lab defended his thesis “Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation”.
Mark Hedglin from the O'Brien lab defended his thesis “Characterization of the Searching Mechanism for a DNA Repair Enzyme”.
Prof. Lei Selected for HHMI Early Career Award
The Howard Hughes Medical Institute has announced that Ming Lei has been awarded an Early Career Scientist award. The award supports scientists who are just beginning their independent research careers, by providing full salary, benefits, and a research budget of $1.5 million over the six-year appointment. The Institute will also cover other expenses, including research space and the purchase of critical equipment.
Interdepartmental Chemical Biology Program sees continued success
Initiated in 2004; the program has grown to include 58 students and 44 faculty members from Biological Chemistry, Biophysics, Chemistry, Medicinal Chemistry and Pharmacology. Click here to read about how the program got its start.