Students

Tonia J. Buchholz

Graduate Student
Research Advisor: David Sherman
M.A., Biochemistry
B.A., Biochemistry
Cohort: 2005-2006
E-mail: toniab@umich.edu

Publications

1. Buchholz, T.J., Geders, T.W., Bartley, F.E., Reynolds, K.A., Smith,J.L., and Sherman, D.H., "Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains", ACS Chem. Biol., 2009, 4, 41-52. [Full Text]

2. Lopanik, N.B., Shields,J.A., Buchholz, T.J., Rath, C.M., Hothersoll, J., Haygood, M.G., Hakansson, K., Thomas, C.M., and Sherman, D.H., "In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont", Chem. Biol, 2008, 15, 1175-1186. [Full Text]

3. Buchholz, T.J., Kittendorf, J.D., Sherman, D.H., "Polyketide Biosynthesis, Modular Polyketide Synthases: Nature's Platform for the Expansion of Structural Diversity?", Wiley Encyclopedia of Chemical Biology, 2008

4. Kittendorf, J.D., Beck, B.J., Buchholz, T.J., Seufert, W., and Sherman, D.H., "Interrogating the Molecular Basis for Multiple Macrolactone Ring Formation by the Pikromycin Polyketide Synthase", Chemistry and Biology, 2007, 14, 944. [Full Text]

5. Demo, S.D., Kirk, C.J., Aujay, M.A., Buchholz, T.J., Dajee, M., Ho, M.N., Jiang, J., Laidig, G.J., Lewis, E.R., Parlati, F., Shenk, K.D., Smyth, M.S., Sun, C.M., Vallone, M.K., Woo, T.M., Molineaux, C.J. and Bennett, M.K., "Antitumor Activity of PR-171, a Novel Irreversuble Inhibitor of the Proteasome", Cancer Res., 2007, 67, 6383. [Full Text]

6. Grüschow, S., Buchholz, T.J., Seufert, W., Dordick, J.S. and Sherman, D.H., "Substrate Profile Analysis and ACP-Mediated Acyl Transfer in Streptomyces coelicolor Type III Polyketide Synthases", ChemBioChem, 2007, 8, 863. [Full Text]

7. Bennett, M.K., Buchholz, T.J., Demo, S.D., Laidig, G.J., Lewis, E.R. and Smyth, M.S., "Compounds for Enzyme Inhibition", U.S./International Patent Applications, 2006 [Full Text]

8. Schuster, M.C., Mann, D.A., Buchholz, T.J., Johnson, K.M., Thomas, W.D., and Kiessling, L.L., "Parallel Synthesis of Glycomimetic Libraries: Targeting a C-Type Lectin", Org. Lett., 2003, 5, 1407. [Full Text]

9. Buchholz, T.J., and Burke, T. J., "Methods and Kits for Assays Utilizing Fluorescence Polarization", U.S./International Patent Applications, 2003 [Full Text]

Presentations

1. Buchholz, T.J., "Protein-protein interactions in type I polyketide synthases", 2007, ChemBio 800 Seminar.