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University of Michigan Chemical Biology Doctoral Program
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Student PublicationsJohn R. Androsavich (Walter Lab) 2. Belokon, Y.N., Bhave, D., D'Addario, D., Groaz, E., North, M. and Tagliazucca, V., "Copper(II)salen catalysed, asymmetric synthesis of α,α-disubstituted amino acids", Tetrahedron, 2003, 60, 1849. [Full Text] 3. Belokon, Y.N., Bhave, D., D'Addario, D., Groaz, E., Maleev, V., North, M. and Pertrosyan, A., "Catalytic, asymmetric synthesis of α,α-disubstituted amino acids", Tetrahedron Lett., 2003, 44, 2045. [Full Text] Angela M. Bopra Tonia J. Buchholz (Sherman Lab) 2. Lopanik, N.B., Shields,J.A., Buchholz, T.J., Rath, C.M., Hothersoll, J., Haygood, M.G., Hakansson, K., Thomas, C.M., and Sherman, D.H., "In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont", Chem. Biol, 2008, 15, 1175-1186. [Full Text] 3. Buchholz, T.J., Kittendorf, J.D., Sherman, D.H., "Polyketide Biosynthesis, Modular Polyketide Synthases: Nature's Platform for the Expansion of Structural Diversity?", Wiley Encyclopedia of Chemical Biology, 2008 4. Kittendorf, J.D., Beck, B.J., Buchholz, T.J., Seufert, W., and Sherman, D.H., "Interrogating the Molecular Basis for Multiple Macrolactone Ring Formation by the Pikromycin Polyketide Synthase", Chemistry and Biology, 2007, 14, 944. [Full Text] 5. Demo, S.D., Kirk, C.J., Aujay, M.A., Buchholz, T.J., Dajee, M., Ho, M.N., Jiang, J., Laidig, G.J., Lewis, E.R., Parlati, F., Shenk, K.D., Smyth, M.S., Sun, C.M., Vallone, M.K., Woo, T.M., Molineaux, C.J. and Bennett, M.K., "Antitumor Activity of PR-171, a Novel Irreversuble Inhibitor of the Proteasome", Cancer Res., 2007, 67, 6383. [Full Text] 6. Grüschow, S., Buchholz, T.J., Seufert, W., Dordick, J.S. and Sherman, D.H., "Substrate Profile Analysis and ACP-Mediated Acyl Transfer in Streptomyces coelicolor Type III Polyketide Synthases", ChemBioChem, 2007, 8, 863. [Full Text] 7. Bennett, M.K., Buchholz, T.J., Demo, S.D., Laidig, G.J., Lewis, E.R. and Smyth, M.S., "Compounds for Enzyme Inhibition", U.S./International Patent Applications, 2006. [Full Text] 8. Schuster, M.C., Mann, D.A., Buchholz, T.J., Johnson, K.M., Thomas, W.J. and Kiessling, L.L., "Parallel Synthesis of Glycomimetic Libraries: Targeting the C-type Lectin Family", Org. Lett., 2003, 5, 1407. [Full Text] 9. Buchholz, T. and Burke, T., "Methods and Kits for Assays Utilizing Flourescence Polarization", U.S. Patent Application, 2003. [Full Text] Lyra (Chia Yin) Chang (Gestwicki Lab) 2. Chang, L., Bertelsen, E.B., Wisén, S., Larsen, E.M., Zuiderweg, E.R., Gestwicki, J.E., "High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK.", Anal. Biochem., 2008, 372,167. [Full Text] 3. Chang, C.Y., Hong, W.W., Chong, P. and Wu, S.C., "Influence of Intron and Exon Splicing Enhancers on Mammalian Cell Expression of a Truncated Spike Protein of SARS-CoV and its Implication for Subunit Vaccine Development", Vaccine, 2006, 24, 1132. [Full Text] Wenjing Chen (Garneau-Tsodikova Lab) John A. Conrad (Palfey Lab) Brian T. DeVree (Sunahara Lab) Christopher G. Evans (Gestwicki Lab) 2. Evans, C.G., Wisen, S., and Gestwicki, J.E., "Heat shock protein 70 and 90 inhibit early atages of amyloid ß(1-42) aggregation in vitro", J. Biol. Chem., 2006, 281, 33182. [Full Text] Tasha M. Francis (Glick Lab) 2. Francis, T.M., Sundberg, T.B., Cleary, J., Groendyke, T., Opipari, A.W. Jr. and Glick, G.D., "Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones", Bioorg. & Med. Chem. Lett., 2006, 16, 2423. [Full Text] 3. Zhou, J., Zong, C., Francis, T.M. and Braun, C.L., "Radiative Exciplexes of 1,2,4,5-Tetracyanobenzene with Sterically Hindered Alkylbenzenes", J. Phys. Chem. A., 2003, 107, 8319. [Full Text] 4. Bruckner, C., McCarthy, J.R., Daniell, H.W., Pendon, Z.D., Ilagan, R.P., Francis, T.M., Ren, L., Birge, R.R. and Frank, H.A., "A Spectroscopic and Computational Study of the Singlet and Triplet Excited States of Synthetic β-Functionalized Chlorins", Chemical Physics, 2003, 294, 285. [Full Text] 5. Zhou, J., Findley, B.R., Francis, T.M., Nytko, E.A. and Braun, C.L., "The Solution Dynamics of Photoinduced Geminate Radical Ion Pairs: Free Ion Formation", Chem. Phys. Lett., 2002, 362, 63. [Full Text] Anne Gillies Alisa Glukhova Mark Hedglin (O'Brien Lab) 2. Krenn Hrubec, K., Marshall, B.L., Hedglin, M., Verdin, E. and Ulrich, S.M., "Design and Evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors", Bioorg. Med. Chem. Lett., 2007, 17, 2874. [Full Text] Jana Jenquin 2. Quinlan, C.L., Rissa, A., Burton, J.R., Costa, A.D., and Garlid, K.D., "Bradykinin cardioprotection is mediated by receptor internalization and mitoKATP opening", J. Mol. Cell. Card., 2006, 40, 894. Leshern Karamchand Cesar Kenaan (Hollenberg Lab) 1. Zhang, H., Kenaan, C., Hamdane, D., Hui Bon Hoa, G., Hollenberg, P.F., "Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the introduction of a De Novo Disulfide bond into Cytochrome P450 2B1", J. Biol. Chem., 2009 (In Press) 3. Marsili, R.T., Laskonis, L.C. and Kenaan, C., "Evaluation of PDMS-based Extraction Techniques and GC-TOFMS for the Analysis of Off-flavor Chemicals in Beer", Amer. Soc. of Brewing Chemists, 2007, 65, 3, 129. [Full Text] Byung Chul Kim Jody K. Lancia (Mapp Lab) 2. Fischer, J.L., Lancia, J.K., Mathur, A. and Smith, M.L., "Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex", Anticancer Res., 2006, 26, 899. 3. Smith, M.L., Lancia, J.K., Mercer, T.I., Ip, C., "Selenium compounds regulate p53 by common and distinctive mechanisms", Anticancer Res., 2004, 24, 1401. Stephen E. Leonard (Carroll Lab)
Rachel A. Leslie (Walter Lab) Yoshi Miyata (Gestwicki Lab) Jamie M. Moser (Dotson Lab) 3. Anderson, M.O., Moser, J., Sherrill, J., Guy, R.K., "A Convenient Procedure for Hydrolysis of Esters in Parallel Synthesis", Synlett, 2004, 13, 2391. [Full Text] Evgenia Nikolova (Al-Hashimi Lab) 2. Pereira, M.J.B., Nikolova, E. N., Hiley, S. L., Jaikaran, D., Collins, R. A. and Walter, N. G., "Single VS Ribozyme Molecules Reveal Dynamic and Hierarchical Folding Toward Catalysis", Journal of Molecular Biolgy, 2008, 382, 496. [Full Text] Tad Ogorzalek Candice E. Paulsen (Carroll Lab) Christopher M. Rath (Sherman Lab) 2. Pfleger, B.F., Kim, Y., Nusca, T.D., Maltseva, N., Lee, J.Y., Rath, C.M., Scaglione, J.B., Janes, B.K., Anderson, A.C., Bergman, N.H., Hanna, P.C., Joachimiak, A., and Sherman, D.H.,"Structural and functional analysis of AsbF: Origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis", Proc. Nat'l. Acad. Sci., 2008, 105, 17133-17138. [Full Text] 3. Amagata, T., Rath, C., Rigot, J.F., Tarlov, N., Tenney, K., Valeriote, F.A. and Crews, P., "Structures and cytoxic properties of trichoverriods and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria", J. Med. Chem., 2003, 46, 4342. [Full Text] Chenxi Shen (Nikolovska-Coleska Lab)
Andrew C. Stelzer (Al-Hashimi Lab) 3. Zhang, Q., Stelzer, A.C., Fisher, C.K. and Al-Hashimi, H.M., "Visualizing spatially correlated dynamics that directs RNA conformational transitions", Nature, 2007, 450, 1263. [Full Text] Bethany S. Strunk (Karbstein Lab) 2. Hewitt, G.F., Strunk, B.S., Marguilies, C., Priputin, T., Wang, X.D., Amey, R., Pabst, B.A., Kosman, D., Reinitz, J. and Arnosti, D.N., "Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient", Development, 1999, 126, 1201. [Full Text] Frederick Stull David M. Thal (Tesmer Lab) 2. Gu, S., He, J., Ho, W.T., Ramineni, S., Thal, D.M., Natesh, R., Tesmer, J.J.G., Hepler, J.R. and Heximer, S.P., "Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members", J. Biol. Chem., 2007. [Full Text] 3. Hanes, J.W., Thal, D.M and Johnson, K.A.,
"Incorporation and Replication of 8-Oxo-deoxyguanosine by the Human Andrea Thompson (Gestwicki Lab) 2. Lipinski, C.A., Tran, N.L., Dooley, A., Pang, Y.-P., Rohl, C., Kloss, J., McDonough, W., Craig, D., Berens, M.E. and Loftus, J.C., "Critical Role of the FERM Domain in Pyk2 Stimulated Glioma Cell Migration", Biochem. Biophys. Res. Commun., 2006, 349, 939. [Full Text] Gabrielle Todd (Walter Lab) 2. Todd G, Karbstein K., "RNA takes center stage." Biopolymers. 2007, 87, 275. [Full Text] Jamie Van Etten (Gafni Lab) Dan Wahl (Glick Lab) Jonas Westergaard Hojfeldt (Mapp Lab) 2. Casey, R.J., Desaulniers, J.P., Hojfeldtb, J.W. and Mapp, A.K., "Expanding the repertoire of small molecule transcriptional activation domains", Bioorg. Med. Chem., 2008. [Full Text] 3. Hojfeldt, J.W., Blakskjaer, P. and Gothelf, K.V., "A cleavable amino-thiol linker for reversible linking of amines to DNA", J. Org. Chem., 2006, 71, 9556. [Full Text] Joel Yates (Bochar Lab) Yaru Zhang 2. Bao, R., Zhang, Y., Zhou, C. Z. and Chen, Y., "Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues", Biochim Biophys Acta, 2009, 1794, 716. [Full Text] 3. Zhang, Z., Bao, R., Zhang, Y., Yu, J., Zhou, C. Z. and Chen, Y., "Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin", Biochim Biophys Acta, 2009, 1794, 124. [Full Text] 4. Lou, X., Zhang, Y., Bao, R., Zhou, C.Z., and Chen, Y., "Purification, Crystallization and Preliminary X-ray diffraction analysis of glutathionylated Trx1 C33S mutant from yeast", Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65, 39-41.[Full Text] 5. Zhang, Y., Bao, R., Zhou, C. Z. and Chen, Y., "Expression, purification, crystallization and preliminary X-ray diffraction analysis of thioredoxin Trx1 from Saccharomyces cerevisiae", Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008, 64, 323. [Full Text] 6. Bao, R., Chen, Y.X., Zhang, Y., and Zhou, C.Z., "Expression, purification, Crystallization and preliminary X-Ray diffraction analysis of mitochondrial thioredoxin Trx3 from Sacchromyces cerevisiae", Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 2006, 62, 1161-1163. [Full Text]
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