Faculty
- Rowena G. Matthews Collegiate Professor in the Life Sciences
Professor of Cell and Developmental Biology
Research:
Using single particle cryo-electron microscopy (cryo-EM) in combination with biophysical, biochemical, and genetic approaches to structurally and functionally characterize biologically important but structurally challenging molecular machines.
Professor of Cell & Developmental Biology
Research:
Mitosis, Cytokinesis, Microtubule, Kinesin, Microscopy, Reconstitution
Warner-Lambert/Parke-Davis Professor in Medicine; Professor of Pharmacology; Associate Chair, Innovation
Research:
Protein folding diseases; Hsp90, Hsp70; molecular chaperones; nitric oxide synthase; ubiquitination and protein quality control; reactive metabolites and mass spectrometry.
- Associate Director of the Program in Chemical Biology
Associate Professor of Biological Chemistry
Research:
We investigate the reaction mechanisms of flavin-dependent enzymes, especially the reactions of O2 and the formation of novel intermediates, using kinetic, spectroscopy, and anything else that helps. Flavoenzymes are constantly being discovered in all areas of biology, making them inviting drug targets, models for detailed studies of structure-function relationships and enzyme evolution. And surprisingly, despite decades of intense enzymology, novel intermediates continue to be discovered
John T Groves Collegiate Professor of Chemistry
Research:
The role of metals in biology. Metalloprotein Design of redox and hydrolytic enzymes and electron transfer proteins. Development of Near Infrared luminescent imaging agents for cellular and animal studies.
George A Lindsay Collegiate Professor of Chemistry and Biophysics
Research:
Biophysical chemistry and inorganic spectroscopy
David Ballou Collegiate Professor of Biological Chemistry
Research:
Enzyme mechanisms, metals in biology, redox regulation
Professor of Chemistry
Research:
Synthetic organic and organometallic chemistry
Professor of Medicinal Chemistry; Professor of Pharmacology; Professor of Biophysics
Research:
Understanding how the functions of human cytochrome P450 enzymes in drug metabolism and in normal physiology (e.g. steroidogenesis) are controlled by the molecular details of specific P450/ligand interactions. Using X-ray crystallography, NMR, and other structural and biophysical techniques, the goal is to facilitate the design of drugs to improve human health across many different human diseases including cancers.
Assistant Professor of Internal Medicine; Assistant Professor of Medicinal Chemistry; Faculty Lead, Drug Repurposing, MICHR
Research:
Drug discovery, drug repurposing and drug development for diabetes and obesity
Research Professor, Life Sciences Institute; Hans W. Vahlteich Professor of Medicinal Chemistry; Professor of Chemistry; Professor of Microbiology and Immunology
Research:
Synthetic chemistry, marine microorganisms, drug discovery
- Director of the Center for Structural Biology, Life Sciences Institute
Margaret J Hunter Collegiate Professor, Life Sciences Institute; Professor of Biological Chemistry
Research:
Protein structure and function using X-ray crystallography
Professor of Pharmacology; Professor of Biophysics; Benedict R Lucchesi Collegiate Professor of Cardiovascular Pharmacology
Research:
The interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities
Assistant Professor of Chemistry; Research Associate Professor of Internal Medicine (Adjunct)
Research:
Chemical and cell biology of protein kinases
Associate Professor of Molecular, Cellular, and Developmental Biology
Research:
Structure/function of membrane proteins, microbial fluoride resistance