Faculty

Associate Professor of Molecular and Integrative Physiology; Associate Professor of Internal Medicine
Expertise: Cancer Chemical Biology
Research:
Tumor metabolism, cancer, pancreatic cancer, autoimmunity
Associate Dean for Academic Programs and Initiatives, U-M Rackham Graduate School; Research Professor, Life Sciences Institute; Edwin Vedejs Collegiate Professor of Chemistry
Expertise: Cancer Chemical Biology
Research:
Discovery of artificial transcriptional regulators
Professor of Chemistry; Professor of Biological Chemistry
Expertise: Chemical Microbiology, Macromolecular Structure and Function
Research:
Enzyme mechanism and structure, protein design
Arthur F. Thurnau, Margaret and Herman Sokol Professor in Medicinal or Synthetic Chemistry; Arthur F. Thurnau Professor of Chemistry
Expertise: Macromolecular Structure and Function
Research:
Synthetic Chemistry and Glycoscience
Assistant Professor of Human Genetics; Faculty Scholar, Center for RNA Biomedicine
Expertise: Macromolecular Structure and Function
Research:
Mechanisms of RNA regulation in stress, aging, and neurological disease
Research Assistant Professor, Life Sciences Institute; Assistant Professor of Cellular & Developmental Biology; Assistant Professor of Biological Chemistry
Expertise: Macromolecular Structure and Function
Research:
In-situ structural biology
Professor of Chemistry
Expertise: Cancer Chemical Biology, Macromolecular Structure and Function
Research:
Natural products with anticancer activity, synthesis, medicinal chemistry, cardiotonic steroids
  • Associate Director of Graduate Students, Program in Chemical Biology
Associate Professor of Molecular, Cellular, and Developmental Biology
Expertise: Cancer Chemical Biology, Macromolecular Structure and Function
Research:
Telomerase, telomeres, cancer, aging biochemistry
Assistant Professor of Biological Chemistry; Faculty Scholar, Center for RNA Biomedicine
Expertise: Cancer Chemical Biology, Macromolecular Structure and Function
Research:
mRNA regulatory features that control protein output
  • Director of Molecular and Cellular Pathology Graduate Program, Medical School
Professor of Pathology
Expertise: Cancer Chemical Biology
Research:
Discovery, design and development of small molecules as new molecularly targeted therapies for cancer
  • Associate Chair of Biological Chemistry
Professor of Biological Chemistry
Expertise: Cancer Chemical Biology, Macromolecular Structure and Function
Research:
Protein/nucleic acid interactions and DNA repair
  • Rowena G. Matthews Collegiate Professor in the Life Sciences
Professor of Cell and Developmental Biology
Expertise: Macromolecular Structure and Function
Research:
Using single particle cryo-electron microscopy (cryo-EM) in combination with biophysical, biochemical, and genetic approaches to structurally and functionally characterize biologically important but structurally challenging molecular machines.
Professor of Cell and Developmental Biology
Expertise: Cancer Chemical Biology
Research:
Mitosis, Cytokinesis, Microtubule, Kinesin, Microscopy, Reconstitution
Warner-Lambert/Parke-Davis Professor in Medicine; Professor of Pharmacology; Associate Chair, Innovation and Wellness
Expertise: Chemical Neurobiology, Macromolecular Structure and Function
Research:
Protein folding diseases; Hsp90, Hsp70; molecular chaperones; nitric oxide synthase; ubiquitination and protein quality control; reactive metabolites and mass spectrometry.
Associate Professor of Biological Chemistry
Expertise: Macromolecular Structure and Function
Research:
We investigate the reaction mechanisms of flavin-dependent enzymes, especially the reactions of O2 and the formation of novel intermediates, using kinetic, spectroscopy, and anything else that helps. Flavoenzymes are constantly being discovered in all areas of biology, making them inviting drug targets, models for detailed studies of structure-function relationships and enzyme evolution. And surprisingly, despite decades of intense enzymology, novel intermediates continue to be discovered

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